Is the Canon RF 100-400mm F5.6-8 IS USM Lens sharp? This page visually answers that question. Shown above are 100% crops from a lab-captured 135mm f/6.3 test image. Observe the contrast and resolution of these results.
Is the Canon RF 100-400mm F5.6-8 IS USM Lens set to 135mm f/6.3 sharper than the Canon RF 100-400mm F5.6-8 IS USM Lens set to 200mm f/16.0? The image quality comparison above also answers that question. Switch between the results to see the sharpness differences between these lenses.